Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

Malaria Journal, September 2010

20815879

Salim Abdulla, Baraka Amuri, Abdunoor M Kabanywanyi, David Ubben, Christine Reynolds, Steve Pascoe, Serge Fitoussi, Ching-Ming Yeh, Marja Nuortti, Romain Séchaud, Günther Kaiser, Gilbert Lefèvre

Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L. During early development of this new formulation, two studies were performed in healthy subjects, one to evaluate the palatability of three flavours of A-L, and a second one to compare the bioavailability of active principles between the dispersible tablet and the tablet (administered crushed and intact).