Title |
Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals
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Published in |
Retrovirology, June 2014
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DOI | 10.1186/1742-4690-11-44 |
Pubmed ID | |
Authors |
Luis M Molinos-Albert, Jorge Carrillo, Marta Curriu, Maria L Rodriguez de la Concepción, Silvia Marfil, Elisabet García, Bonaventura Clotet, Julià Blanco |
Abstract |
The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of these antibodies in HIV infected individuals.We have quantified and characterized anti-MPER antibodies by ELISA and by flow cytometry using a collection of mini gp41-derived proteins expressed on the surface of 293T cells. Longitudinal plasma samples from 35 HIV-1 infected individuals were assayed for MPER recognition and MPER-dependent neutralizing capacity using HIV-2 viruses engrafted with HIV-1 MPER sequences. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 33% |
Student > Ph. D. Student | 7 | 19% |
Student > Master | 5 | 14% |
Professor > Associate Professor | 3 | 8% |
Professor | 3 | 8% |
Other | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 11 | 31% |
Agricultural and Biological Sciences | 9 | 25% |
Biochemistry, Genetics and Molecular Biology | 6 | 17% |
Medicine and Dentistry | 3 | 8% |
Chemistry | 3 | 8% |
Other | 4 | 11% |