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Interleukin-17 regulation: an attractive therapeutic approach for asthma

Overview of attention for article published in Respiratory Research, June 2010
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Title
Interleukin-17 regulation: an attractive therapeutic approach for asthma
Published in
Respiratory Research, June 2010
DOI 10.1186/1465-9921-11-78
Pubmed ID
Authors

Seoung Ju Park, Yong Chul Lee

Abstract

Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orchestrates the neutrophilic influx into the airways and also enhances T-helper 2 (Th2) cell-mediated eosinophilic airway inflammation in asthma. Recent studies have demonstrated that not only inhibitor of IL-17 per se but also diverse regulators of IL-17 expression reduce antigen-induced airway inflammation, bronchial hyperresponsiveness, and Th2 cytokine levels in animal models of asthma. This review will summarize the role of IL-17 in the context of allergic airway inflammation and discuss the therapeutic potential of various strategies targeting IL-17 for asthma.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Brazil 2 2%
Germany 1 <1%
Taiwan 1 <1%
United Kingdom 1 <1%
Unknown 105 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 19%
Student > Ph. D. Student 19 17%
Student > Master 15 13%
Student > Bachelor 15 13%
Other 7 6%
Other 19 17%
Unknown 16 14%
Readers by discipline Count As %
Medicine and Dentistry 32 28%
Agricultural and Biological Sciences 28 25%
Pharmacology, Toxicology and Pharmaceutical Science 8 7%
Biochemistry, Genetics and Molecular Biology 7 6%
Immunology and Microbiology 7 6%
Other 7 6%
Unknown 24 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2013.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Respiratory Research
#2,216
of 3,062 outputs
Outputs of similar age
#79,381
of 96,577 outputs
Outputs of similar age from Respiratory Research
#11
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,577 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.