Title |
Interleukin-17 regulation: an attractive therapeutic approach for asthma
|
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Published in |
Respiratory Research, June 2010
|
DOI | 10.1186/1465-9921-11-78 |
Pubmed ID | |
Authors |
Seoung Ju Park, Yong Chul Lee |
Abstract |
Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orchestrates the neutrophilic influx into the airways and also enhances T-helper 2 (Th2) cell-mediated eosinophilic airway inflammation in asthma. Recent studies have demonstrated that not only inhibitor of IL-17 per se but also diverse regulators of IL-17 expression reduce antigen-induced airway inflammation, bronchial hyperresponsiveness, and Th2 cytokine levels in animal models of asthma. This review will summarize the role of IL-17 in the context of allergic airway inflammation and discuss the therapeutic potential of various strategies targeting IL-17 for asthma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 3% |
Brazil | 2 | 2% |
Germany | 1 | <1% |
Taiwan | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 105 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 19% |
Student > Ph. D. Student | 19 | 17% |
Student > Master | 15 | 13% |
Student > Bachelor | 15 | 13% |
Other | 7 | 6% |
Other | 19 | 17% |
Unknown | 16 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 28% |
Agricultural and Biological Sciences | 28 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Immunology and Microbiology | 7 | 6% |
Other | 7 | 6% |
Unknown | 24 | 21% |