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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy
|
|---|---|
| Published in |
Breast Cancer Research, May 2014
|
| DOI | 10.1186/bcr3655 |
| Pubmed ID | |
| Authors |
Marieke A Vollebergh, Esther H Lips, Petra M Nederlof, Lodewyk FA Wessels, Jelle Wesseling, Marc J vd Vijver, Elisabeth GE de Vries, Harm van Tinteren, Jos Jonkers, Michael Hauptmann, Sjoerd Rodenhuis, Sabine C Linn |
| Abstract |
BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand-break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused by BRCA-mutations, and by other mechanisms. To identify HRD, studies have focused on triple-negative (TN) breast cancers as these resemble BRCA1-mutated breast cancer closely and might also share this hypersensitivity. However, ways to identify HRD in non-BRCA-mutated, estrogen-receptor (ER)-positive breast cancers have remained elusive. The current study provides evidence that genomic patterns resembling BRCA1- or BRCA2-mutated breast cancers can identify breast cancer patients with TN as well as ER-positive, HER2-negative tumors that are sensitive to intensified, DSB-inducing chemotherapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 113 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 22% |
| Researcher | 21 | 18% |
| Student > Master | 13 | 11% |
| Other | 10 | 9% |
| Professor > Associate Professor | 8 | 7% |
| Other | 19 | 16% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 35% |
| Biochemistry, Genetics and Molecular Biology | 25 | 22% |
| Agricultural and Biological Sciences | 14 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Other | 8 | 7% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#3,621,892
of 25,373,627 outputs
Outputs from Breast Cancer Research
#417
of 2,052 outputs
Outputs of similar age
#34,884
of 241,493 outputs
Outputs of similar age from Breast Cancer Research
#7
of 37 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,493 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.