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A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population

Overview of attention for article published in BMC Infectious Diseases, June 2014
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Title
A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population
Published in
BMC Infectious Diseases, June 2014
DOI 10.1186/1471-2334-14-316
Pubmed ID
Authors

George O Ogola, Collins Ouma, Walter GZO Jura, Erick O Muok, Robert Colebunders, Pauline N Mwinzi

Abstract

Human Immunodeficiency Virus (HIV) and Schistosomiasis co-infection is common among residents at the shores of Lake Victoria in Kenya. About 36% of this population initiating antiretroviral therapy (ART) experience Immune Reconstitution Inflammatory Syndrome (IRIS) that complicates recovery. Several IL-23R alleles have been associated with susceptibility to both autoimmune and inflammatory diseases through T-helper type 17 (TH17) cells. However, whether or not variants within the IL-23R increase susceptibility to IRIS in western Kenya is unknown. The objective of the current study was to determine the association between IL-23R gene polymorphisms, CD4+ cell counts and HIV RNA levels and IRIS in HIV and Schistosoma mansoni co-infected patients undergoing highly active anti-retroviral therapy (HAART).

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 22%
Researcher 7 15%
Student > Ph. D. Student 7 15%
Lecturer 2 4%
Other 2 4%
Other 8 17%
Unknown 10 22%
Readers by discipline Count As %
Medicine and Dentistry 18 39%
Biochemistry, Genetics and Molecular Biology 5 11%
Social Sciences 4 9%
Agricultural and Biological Sciences 3 7%
Immunology and Microbiology 2 4%
Other 3 7%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from BMC Infectious Diseases
#6,454
of 7,665 outputs
Outputs of similar age
#193,770
of 229,145 outputs
Outputs of similar age from BMC Infectious Diseases
#155
of 169 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,665 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,145 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.