Title |
Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes
|
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Published in |
BMC Complementary Medicine and Therapies, August 2011
|
DOI | 10.1186/1472-6882-11-66 |
Pubmed ID | |
Authors |
Nahid Akhtar, Mark JS Miller, Tariq M Haqqi |
Abstract |
Conventional treatments for the articular diseases are often effective for symptom relief, but can also cause significant side effects and do not slow the progression of the disease. Several natural substances have been shown to be effective at relieving the symptoms of osteoarthritis (OA), and preliminary evidence suggests that some of these compounds may exert a favorable influence on the course of the disease. The objective of this study was to investigate the anti-inflammatory/chondroprotective potential of a Herbal and amino acid mixture containing extract of the Uncaria tomentosa, Boswellia spp., Lepidium meyenii and L-Leucine on the IL-1β-induced production of nitric oxide (NO), glycosaminoglycan (GAG), matrix metalloproteinases (MMPs), aggrecan (ACAN) and type II collagen (COL2A1) in human OA chondrocytes and OA cartilage explants. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 50% |
United Kingdom | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Unknown | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
United States | 1 | 1% |
Sweden | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 14% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 8 | 11% |
Student > Bachelor | 8 | 11% |
Other | 14 | 20% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 18 | 26% |
Medicine and Dentistry | 16 | 23% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Unspecified | 2 | 3% |
Other | 6 | 9% |
Unknown | 18 | 26% |