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Diurnal variation of NMR based blood metabolites in calves fed a high plane of milk replacer: a pilot study

Overview of attention for article published in BMC Veterinary Research, August 2017
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Title
Diurnal variation of NMR based blood metabolites in calves fed a high plane of milk replacer: a pilot study
Published in
BMC Veterinary Research, August 2017
DOI 10.1186/s12917-017-1185-2
Pubmed ID
Authors

Morteza H. Ghaffari, Jayden A. R. MacPherson, Harma Berends, Michael A. Steele

Abstract

Blood profiles have been used to monitor herd health status, diagnose disorders, and predict the risk of diseases in cattle and calves. Characterizing plasma metabolites in dairy calves could provide further insight into daily metabolic variations and the mechanisms that lead to metabolic diseases. In addition, by understanding physiological ranges of plasma metabolites relative to meal and the time of feeding in healthy animals, veterinarians can accurately diagnose abnormalities with a blood test. For diagnostic purposes, nuclear magnetic resonance (NMR) spectroscopy shows promise as a new and reliable method to determine a large number of blood metabolites simultaneously. Results demonstrated that the concentration of specific metabolites in plasma (i.e., lysine, isoleucine, leucine, tyrosine, glutamine, creatine, and 1-methylhistidine) fluctuated around meal times, while others (i.e., glutamic acid, methanol, formic acid, and acetic acid) maintained a stable temporal concentration. In addition to temporal changes in concentration, results also characterized differences for overall plasma metabolite concentrations; for example, methionine had the lowest (38 μM) while glutamine had the highest concentration (239 μM) amongst plasma AA. This is the first report describing how the plasma metabolome changes during 24-h period in young calves fed an elevated plane of milk replacer twice daily. Data from this pilot study will help to establish reference standards for future metabolic diagnostics in dairy calves. In addition, this pilot study illustrated that feeding milk replacer may influence plasma metabolite concentrations. With the rapid implementation of blood metabolomics in monitoring animal health, it is then important to consider the time of feeding during the day when interpreting metabolomics analysis results.

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Mendeley readers

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The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Student > Master 4 20%
Other 1 5%
Unspecified 1 5%
Researcher 1 5%
Other 1 5%
Unknown 7 35%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 30%
Veterinary Science and Veterinary Medicine 3 15%
Engineering 2 10%
Unspecified 1 5%
Chemistry 1 5%
Other 1 5%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2017.
All research outputs
#18,569,430
of 22,999,744 outputs
Outputs from BMC Veterinary Research
#1,931
of 3,064 outputs
Outputs of similar age
#243,354
of 317,355 outputs
Outputs of similar age from BMC Veterinary Research
#54
of 75 outputs
Altmetric has tracked 22,999,744 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,064 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.