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Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses

Overview of attention for article published in Acta Neuropathologica Communications, June 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

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1 tweeter
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1 patent

Citations

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23 Dimensions

Readers on

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57 Mendeley
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Title
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses
Published in
Acta Neuropathologica Communications, June 2014
DOI 10.1186/2051-5960-2-63
Pubmed ID
Authors

Nikita Rudinskiy, Jonathan M Hawkes, Susanne Wegmann, Kishore V Kuchibhotla, Alona Muzikansky, Rebecca A Betensky, Tara L Spires-Jones, Bradley T Hyman

Abstract

Intraneuronal neurofibrillary tangles (NFTs) - a characteristic pathological feature of Alzheimer's and several other neurodegenerative diseases - are considered a major target for drug development. Tangle load correlates well with the severity of cognitive symptoms and mouse models of tauopathy are behaviorally impaired. However, there is little evidence that NFTs directly impact physiological properties of host neurons. Here we used a transgenic mouse model of tauopathy to study how advanced tau pathology in different brain regions affects activity-driven expression of immediate-early gene Arc required for experience-dependent consolidation of long-term memories. We demonstrate in vivo that visual cortex neurons with tangles are as likely to express comparable amounts of Arc in response to structured visual stimulation as their neighbors without tangles. Probability of experience-dependent Arc response was not affected by tau tangles in both visual cortex and hippocampal pyramidal neurons as determined postmortem. Moreover, whole brain analysis showed that network-wide activity-driven Arc expression was not affected by tau pathology in any of the brain regions, including brain areas with the highest tangle load. Our findings suggest that intraneuronal NFTs do not affect signaling cascades leading to experience-dependent gene expression required for long-term synaptic plasticity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 26%
Student > Ph. D. Student 12 21%
Student > Bachelor 6 11%
Student > Master 6 11%
Professor 3 5%
Other 8 14%
Unknown 7 12%
Readers by discipline Count As %
Neuroscience 21 37%
Agricultural and Biological Sciences 11 19%
Medicine and Dentistry 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Psychology 2 4%
Other 8 14%
Unknown 7 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2015.
All research outputs
#7,200,430
of 22,757,090 outputs
Outputs from Acta Neuropathologica Communications
#940
of 1,369 outputs
Outputs of similar age
#70,361
of 229,145 outputs
Outputs of similar age from Acta Neuropathologica Communications
#5
of 21 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.