Title |
Cerebral microbleeds: overview and implications in cognitive impairment
|
---|---|
Published in |
Alzheimer's Research & Therapy, June 2014
|
DOI | 10.1186/alzrt263 |
Pubmed ID | |
Authors |
Sergi Martinez-Ramirez, Steven M Greenberg, Anand Viswanathan |
Abstract |
Cerebral microbleeds (MBs) are small chronic brain hemorrhages which are likely caused by structural abnormalities of the small vessels of the brain. Owing to the paramagnetic properties of blood degradation products, MBs can be detected in vivo by using specific magnetic resonance imaging (MRI) sequences. Over the last decades, the implementation of these MRI sequences in both epidemiological and clinical studies has revealed MBs as a common finding in many different populations, including healthy individuals. Also, the topographic distribution of these MBs has been shown to be potentially associated with specific underlying vasculopathies. However, the clinical and prognostic significance of these small hemorrhages is still a matter of debate as well as a focus of extensive research. In this article, we aim to review the current knowledge on the pathophysiology and clinical implications of MBs, with special emphasis on the links between lobar MBs, cerebral amyloid angiopathy, and Alzheimer's disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 25% |
United States | 1 | 13% |
Canada | 1 | 13% |
Sweden | 1 | 13% |
Venezuela, Bolivarian Republic of | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Japan | 1 | <1% |
Netherlands | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 192 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 20% |
Researcher | 37 | 19% |
Student > Bachelor | 22 | 11% |
Student > Master | 20 | 10% |
Other | 16 | 8% |
Other | 30 | 15% |
Unknown | 34 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 58 | 29% |
Neuroscience | 42 | 21% |
Engineering | 12 | 6% |
Psychology | 10 | 5% |
Agricultural and Biological Sciences | 10 | 5% |
Other | 25 | 13% |
Unknown | 41 | 21% |