Title |
Peripheral Administration of Morphine Attenuates Postincisional Pain by Regulating Macrophage Polarization through COX-2-Dependent Pathway
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Published in |
Molecular Pain, January 2014
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DOI | 10.1186/1744-8069-10-36 |
Pubmed ID | |
Authors |
Kohei Godai, Maiko Hasegawa-Moriyama, Tae Kurimoto, Takayuki Saito, Tomotsugu Yamada, Takahiro Sato, Masayasu Kojima, Yuichi Kanmura |
Abstract |
Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by macrophage polarity, often referred to as proinflammatory (M1) or anti-inflammatory (M2) macrophages. Although opioids such as morphine are known to alter the inflammatory milieu of incisional wounds through interactions with immunocytes, the macrophage-mediated effects of morphine on the development of postincisional pain have not been well investigated. In this study, we examined how morphine alters pain hypersensitivity through phenotypic shifts in local macrophages during the course of incision-induced inflammation. |
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Mendeley readers
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Student > Master | 9 | 22% |
Student > Ph. D. Student | 6 | 15% |
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