Title |
N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats
|
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Published in |
Respiratory Research, June 2014
|
DOI | 10.1186/1465-9921-15-65 |
Pubmed ID | |
Authors |
Marie-Camille Chaumais, Benoît Ranchoux, David Montani, Peter Dorfmüller, Ly Tu, Florence Lecerf, Nicolas Raymond, Christophe Guignabert, Laura Price, Gérald Simonneau, Sylvia Cohen-Kaminsky, Marc Humbert, Frédéric Perros |
Abstract |
The outcome of patients suffering from pulmonary arterial hypertension (PAH) are predominantly determined by the response of the right ventricle to the increase afterload secondary to high vascular pulmonary resistance. However, little is known about the effects of the current available or experimental PAH treatments on the heart. Recently, inflammation has been implicated in the pathophysiology of PAH. N-acetylcysteine (NAC), a well-known safe anti-oxidant drug, has immuno-modulatory and cardioprotective properties. We therefore hypothesized that NAC could reduce the severity of pulmonary hypertension (PH) in rats exposed to monocrotaline (MCT), lowering inflammation and preserving pulmonary vascular system and right heart function. |
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