Title |
Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission
|
---|---|
Published in |
Malaria Journal, June 2014
|
DOI | 10.1186/1475-2875-13-233 |
Pubmed ID | |
Authors |
Alicia Arnott, Johanna Wapling, Ivo Mueller, Paul A Ramsland, Peter M Siba, John C Reeder, Alyssa E Barry |
Abstract |
As Plasmodium falciparum and Plasmodium vivax co-exist in most malaria-endemic regions outside sub-Saharan Africa, malaria control strategies in these areas must target both species in order to succeed. Population genetic analyses can predict the effectiveness of interventions including vaccines, by providing insight into patterns of diversity and evolution. The aim of this study was to investigate the population genetics of leading malaria vaccine candidate AMA1 in sympatric P. falciparum and P. vivax populations of Papua New Guinea (PNG), an area of similarly high prevalence (Pf = 22.3 to 38.8%, Pv = 15.3 to 31.8%). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 75 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 22% |
Researcher | 15 | 19% |
Student > Ph. D. Student | 13 | 17% |
Student > Postgraduate | 5 | 6% |
Student > Bachelor | 4 | 5% |
Other | 12 | 16% |
Unknown | 11 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 22% |
Agricultural and Biological Sciences | 17 | 22% |
Medicine and Dentistry | 12 | 16% |
Immunology and Microbiology | 6 | 8% |
Nursing and Health Professions | 3 | 4% |
Other | 8 | 10% |
Unknown | 14 | 18% |