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Mendeley readers
| Title |
Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5γ2 signaling pathway
|
|---|---|
| Published in |
BMC Cancer, March 2014
|
| DOI | 10.1186/1471-2407-14-193 |
| Pubmed ID | |
| Authors |
Jing-Tao Zhang, Wei Sun, Wen-Zhong Zhang, Chun-Yan Ge, Zhong-Yan Liu, Ze-Ming Zhao, Xing-Sui Lu, Yue-Zu Fan |
| Abstract |
Vasculogenic mimicry (VM) is a novel tumor blood supply in some highly aggressive malignant tumors. Recently, we reported VM existed in gallbladder carcinomas (GBCs) and the formation of the special passage through the activation of the PI3K/MMPs/Ln-5γ2 signaling pathway. GBC is a highly aggressive malignant tumor with disappointing treatments and a poor prognosis. Norcantharidin (NCTD) has shown to have multiple antitumor activities against GBCs, etc; however the exact mechanism is not thoroughly elucidated. In this study, we firstly investigated the anti-VM activity of NCTD as a VM inhibitor for GBCs and its underlying mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 103 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 4% |
| Researcher | 2 | 2% |
| Student > Ph. D. Student | 2 | 2% |
| Student > Doctoral Student | 1 | <1% |
| Student > Master | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 92 | 89% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 4% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Agricultural and Biological Sciences | 1 | <1% |
| Materials Science | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 92 | 89% |