Title |
Identification and characterization of an operon, msaABCR, that controls virulence and biofilm development in Staphylococcus aureus
|
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Published in |
BMC Microbiology, June 2014
|
DOI | 10.1186/1471-2180-14-154 |
Pubmed ID | |
Authors |
Gyan S Sahukhal, Mohamed O Elasri |
Abstract |
Community-acquired, methicillin-resistant Staphylococcus aureus strains often cause localized infections in immunocompromised hosts, but some strains show enhanced virulence leading to severe infections even among healthy individuals with no predisposing risk factors. The genetic basis for this enhanced virulence has yet to be determined. S. aureus possesses a wide variety of virulence factors, the expression of which is carefully coordinated by a variety of regulators. Several virulence regulators have been well characterized, but others have yet to be thoroughly investigated. Previously, we identified the msa gene as a regulator of several virulence genes, biofilm development, and antibiotic resistance. We also found evidence of the involvement of upstream genes in msa function. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 16% |
Researcher | 7 | 16% |
Student > Master | 7 | 16% |
Student > Doctoral Student | 4 | 9% |
Professor | 3 | 7% |
Other | 6 | 13% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 22% |
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Immunology and Microbiology | 4 | 9% |
Medicine and Dentistry | 3 | 7% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 3 | 7% |
Unknown | 14 | 31% |