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Development of cross-resistance by Aspergillus fumigatus to clinical azoles following exposure to prochloraz, an agricultural azole

Overview of attention for article published in BMC Microbiology, June 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

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4 tweeters

Citations

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44 Dimensions

Readers on

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66 Mendeley
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Title
Development of cross-resistance by Aspergillus fumigatus to clinical azoles following exposure to prochloraz, an agricultural azole
Published in
BMC Microbiology, June 2014
DOI 10.1186/1471-2180-14-155
Pubmed ID
Authors

Isabel Faria-Ramos, Sofia Farinha, João Neves-Maia, Pedro Ribeiro Tavares, Isabel M Miranda, Letícia M Estevinho, Cidália Pina-Vaz, Acácio G Rodrigues

Abstract

The purpose of this study was to unveil whether azole antifungals used in agriculture, similar to the clinical azoles used in humans, can evoke resistance among relevant human pathogens like Aspergillus fumigatus, an ubiquitous agent in nature. Additionally, cross-resistance with clinical azoles was investigated. Antifungal susceptibility testing of environmental and clinical isolates of A. fumigatus was performed according to the CLSI M38-A2 protocol. In vitro induction assays were conducted involving daily incubation of susceptible A. fumigatus isolates, at 35oC and 180 rpm, in fresh GYEP broth medium supplemented with Prochloraz (PCZ), a potent agricultural antifungal, for a period of 30 days. Minimal inhibitory concentrations (MIC) of PCZ and clinical azoles were monitored every ten days. In order to assess the stability of the developed MIC, the strains were afterwards sub-cultured for an additional 30 days in the absence of antifungal. Along the in vitro induction process, microscopic and macroscopic cultural observations were registered.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Denmark 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 21%
Researcher 10 15%
Student > Bachelor 9 14%
Student > Master 8 12%
Student > Doctoral Student 6 9%
Other 12 18%
Unknown 7 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 18%
Immunology and Microbiology 11 17%
Agricultural and Biological Sciences 11 17%
Medicine and Dentistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Other 6 9%
Unknown 15 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2015.
All research outputs
#12,513,444
of 21,340,745 outputs
Outputs from BMC Microbiology
#1,180
of 3,044 outputs
Outputs of similar age
#96,942
of 205,869 outputs
Outputs of similar age from BMC Microbiology
#1
of 1 outputs
Altmetric has tracked 21,340,745 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,044 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,869 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them