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X Demographics
Mendeley readers
| Title |
Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia
|
|---|---|
| Published in |
Trials, November 2013
|
| DOI | 10.1186/1745-6215-14-402 |
| Pubmed ID | |
| Authors |
Joanna M Zakrzewska, Joanne Palmer, Dominik A Ettlin, Mark Obermann, Gerard MP Giblin, Valerie Morisset, Simon Tate, Kevin Gunn |
| Abstract |
Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability resulting in sub-optimal pain control. CNV1014802 is a novel sodium channel blocker that is being assessed in the treatment of trigeminal neuralgia. Due to the severity of the condition, it is not ethical to conduct a traditional placebo-controlled randomized controlled trial. It is also difficult to use an active control such as carbamazepine, the current gold standard, because of its complex pharmacology and potential for drug interactions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 99 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 18% |
| Researcher | 16 | 16% |
| Student > Bachelor | 8 | 8% |
| Other | 7 | 7% |
| Student > Ph. D. Student | 7 | 7% |
| Other | 16 | 16% |
| Unknown | 28 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 32% |
| Agricultural and Biological Sciences | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Neuroscience | 6 | 6% |
| Nursing and Health Professions | 2 | 2% |
| Other | 15 | 15% |
| Unknown | 29 | 29% |