Title |
Adrenomedullin: a vasodilator to treat sepsis?
|
---|---|
Published in |
Critical Care, June 2014
|
DOI | 10.1186/cc13924 |
Pubmed ID | |
Authors |
Jérôme Pugin |
Abstract |
Adrenomedullin is a vasodilatory polypeptide with pleiotropic effects secreted by various organs. Adrenomedullin is produced first as a prepropeptide, and then cleaved into mature adrenomedullin and mid-regional proadrenomedullin. Whereas levels of the latter have been shown to correlate with severity of sepsis and carry prognostic value, adrenomedullin plays a role in vascular tone homeostasis. In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. Since adrenomedullin is a strong vasodilatory molecule, further studies are needed to evaluate its potential as a future treatment of sepsis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 17% |
Student > Postgraduate | 3 | 13% |
Student > Doctoral Student | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Student > Master | 2 | 8% |
Other | 3 | 13% |
Unknown | 8 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 63% |
Agricultural and Biological Sciences | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Unknown | 7 | 29% |