Title |
A quantitative account of genomic island acquisitions in prokaryotes
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Published in |
BMC Genomics, August 2011
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DOI | 10.1186/1471-2164-12-427 |
Pubmed ID | |
Authors |
Tom E Roos, Mark WJ van Passel |
Abstract |
Microbial genomes do not merely evolve through the slow accumulation of mutations, but also, and often more dramatically, by taking up new DNA in a process called horizontal gene transfer. These innovation leaps in the acquisition of new traits can take place via the introgression of single genes, but also through the acquisition of large gene clusters, which are termed Genomic Islands. Since only a small proportion of all the DNA diversity has been sequenced, it can be hard to find the appropriate donors for acquired genes via sequence alignments from databases. In contrast, relative oligonucleotide frequencies represent a remarkably stable genomic signature in prokaryotes, which facilitates compositional comparisons as an alignment-free alternative for phylogenetic relatedness. In this project, we test whether Genomic Islands identified in individual bacterial genomes have a similar genomic signature, in terms of relative dinucleotide frequencies, and can therefore be expected to originate from a common donor species. |
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Unknown | 41 | 87% |
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Student > Bachelor | 3 | 6% |
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Unknown | 4 | 9% |
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Immunology and Microbiology | 1 | 2% |
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Unknown | 5 | 11% |