Title |
Fluoxetine for Autistic Behaviors (FAB trial): study protocol for a randomized controlled trial in children and adolescents with autism
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Published in |
Trials, June 2014
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DOI | 10.1186/1745-6215-15-230 |
Pubmed ID | |
Authors |
Anissa Mouti, Dinah Reddihough, Catherine Marraffa, Philip Hazell, John Wray, Katherine Lee, Michael Kohn |
Abstract |
Serotonin reuptake inhibitors (SSRIs) are commonly prescribed off-label for children with autism. To date, clinical trials examining the use of SSRIs in autism have been limited by small sample sizes and inconclusive results. The efficacy and safety of SSRIs for moderating autistic behaviors is yet to be adequately examined to provide evidence to support current clinical practice. The aim of the Fluoxetine for Autistic Behaviors (FAB) study is to determine the efficacy and safety of low dose fluoxetine compared with placebo, for reducing the frequency and severity of repetitive stereotypic behaviors in children and adolescents with an autism spectrum disorder (ASD). The relationship between the effectiveness of fluoxetine treatment and serotonin transporter genotype will also be explored. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Canada | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | <1% |
France | 1 | <1% |
Unknown | 157 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 28 | 18% |
Researcher | 24 | 15% |
Student > Bachelor | 17 | 11% |
Student > Ph. D. Student | 16 | 10% |
Student > Doctoral Student | 8 | 5% |
Other | 31 | 19% |
Unknown | 35 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 23% |
Psychology | 35 | 22% |
Agricultural and Biological Sciences | 10 | 6% |
Nursing and Health Professions | 9 | 6% |
Social Sciences | 8 | 5% |
Other | 21 | 13% |
Unknown | 40 | 25% |