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Fluoxetine for Autistic Behaviors (FAB trial): study protocol for a randomized controlled trial in children and adolescents with autism

Overview of attention for article published in Trials, June 2014
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Title
Fluoxetine for Autistic Behaviors (FAB trial): study protocol for a randomized controlled trial in children and adolescents with autism
Published in
Trials, June 2014
DOI 10.1186/1745-6215-15-230
Pubmed ID
Authors

Anissa Mouti, Dinah Reddihough, Catherine Marraffa, Philip Hazell, John Wray, Katherine Lee, Michael Kohn

Abstract

Serotonin reuptake inhibitors (SSRIs) are commonly prescribed off-label for children with autism. To date, clinical trials examining the use of SSRIs in autism have been limited by small sample sizes and inconclusive results. The efficacy and safety of SSRIs for moderating autistic behaviors is yet to be adequately examined to provide evidence to support current clinical practice. The aim of the Fluoxetine for Autistic Behaviors (FAB) study is to determine the efficacy and safety of low dose fluoxetine compared with placebo, for reducing the frequency and severity of repetitive stereotypic behaviors in children and adolescents with an autism spectrum disorder (ASD). The relationship between the effectiveness of fluoxetine treatment and serotonin transporter genotype will also be explored.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
France 1 <1%
Unknown 157 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 28 18%
Researcher 24 15%
Student > Bachelor 17 11%
Student > Ph. D. Student 16 10%
Student > Doctoral Student 8 5%
Other 31 19%
Unknown 35 22%
Readers by discipline Count As %
Medicine and Dentistry 36 23%
Psychology 35 22%
Agricultural and Biological Sciences 10 6%
Nursing and Health Professions 9 6%
Social Sciences 8 5%
Other 21 13%
Unknown 40 25%