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Mendeley readers
| Title |
Effect of ginseng extract on the TGF-β1 signaling pathway in CCl4-induced liver fibrosis in rats
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|---|---|
| Published in |
BMC Complementary Medicine and Therapies, January 2017
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| DOI | 10.1186/s12906-016-1507-0 |
| Pubmed ID | |
| Authors |
Mohamed M. Hafez, Sherifa S. Hamed, Manal F. El-Khadragy, Zeinab K. Hassan, Salim S. Al Rejaie, Mohamed M. Sayed-Ahmed, Naif O. Al-Harbi, Khalid A. Al-Hosaini, Mohamed M. Al-Harbi, Ali R. Alhoshani, Othman A. Al-Shabanah, Shakir Dekhal Alsharari |
| Abstract |
Liver diseases are major global health problems. Ginseng extract has antioxidant, immune-modulatory and anti-inflammatory activities. This study investigated the effect of ginseng extract on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Male Wistar rats were divided into four groups: control group, ginseng group, CCl4 group and CCl4 + ginseng group. Liver injury was induced by the intraperitoneal (I.P) injection of 3 ml/kg CCl4 (30% in olive oil) weekly for 8 weeks. The control group was I.P injected with olive oil. The expression of genes encoding transforming growth factor beta (TGF-β), type I TGF-β receptor (TβR-1), type II TGF-β receptor (TβR-II), mothers against decapentaplegic homolog 2 (Smad2), Smad3, Smad4, matrix metalloproteinase 2 (MMP2), MMP9, tissue inhibitor matrix metalloproteinase-1 (TIMP-1), Collagen 1a2 (Col1a2), Collagen 3a1 (Col3a1), interleukin-8 (IL-8) and interleukin -10 (IL-10) were measured by real-time PCR. Treatment with ginseng extract decreased hepatic fat deposition and lowered hepatic reticular fiber accumulation compared with the CCl4 group. The CCl4 group showed a significant increase in hepatotoxicity biomarkers and up-regulation of the expression of genes encoding TGF-β, TβR-I, TβR-II, MMP2, MMP9, Smad-2,-3, -4, and IL-8 compared with the control group. However, CCl4 administration resulted in the significant down-regulation of IL-10 mRNA expression compared with the control group. Interestingly, ginseng extract supplementation completely reversed the biochemical markers of hepatotoxicity and the gene expression alterations induced by CCl4. ginseng extract had an anti-fibrosis effect via the regulation of the TGF-β1/Smad signaling pathway in the CCl4-induced liver fibrosis model. The major target was the inhibition of the expression of TGF-β1, Smad2, and Smad3. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 15% |
| Researcher | 6 | 13% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Bachelor | 3 | 6% |
| Professor | 3 | 6% |
| Other | 8 | 17% |
| Unknown | 16 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 19% |
| Agricultural and Biological Sciences | 5 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Medicine and Dentistry | 2 | 4% |
| Engineering | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 23 | 49% |