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Predictors of Chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

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1 news outlet
twitter
2 tweeters
wikipedia
4 Wikipedia pages

Citations

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92 Dimensions

Readers on

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146 Mendeley
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Title
Predictors of Chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4137
Pubmed ID
Authors

Patrick Gérardin, Adrian Fianu, Alain Michault, Corinne Mussard, Karim Boussaïd, Olivier Rollot, Philippe Grivard, Somar Kassab, Eric Bouquillard, Gianandrea Borgherini, Bernard-Alex Gaüzère, Denis Malvy, Gérard Bréart, François Favier

Abstract

ABSTRACT: INTRODUCTION: Long-lasting relapsing or lingering rheumatic musculoskeletal pain (RMSP) is the hallmark of Chikungunya virus (CHIKV) rheumatism (CHIK-R). Little is known on their prognostic factors. The aim of this prognostic study was to search the determinants of lingering or relapsing RMSP indicative of CHIK-R. METHODS: Three hundred and forty-six infected adults (age ≥ 15 years) having declared RMSP at disease onset were extracted from the TELECHIK cohort study, Reunion island, and analyzed using a multinomial logistic regression model. We also searched for the predictors of CHIKV-specific IgG titres, assessed at the time of a serosurvey, using multiple linear regression analysis. RESULTS: Of these, 111 (32.1%) reported relapsing RMSP, 150 (43.3%) lingering RMSP, and 85 (24.6%) had fully recovered (reference group) on average two years after acute infection. In the final model controlling for gender, the determinants of relapsing RMSP were the age 45-59 years (adjusted OR: 2.9, 95% CI: 1.0, 8.6) or greater or equal than 60 years (adjusted OR: 10.4, 95% CI: 3.5, 31.1), severe rheumatic involvement (fever, at least six joints plus four other symptoms) at presentation (adjusted OR: 3.6, 95% CI: 1.5, 8.2), and CHIKV-specific IgG titres (adjusted OR: 3.2, 95% CI: 1.8, 5.5, per one unit increase). Prognostic factors for lingering RMSP were age 45-59 years (adjusted OR: 6.4, 95% CI: 1.8, 22.1) or greater or equal than 60 years (adjusted OR: 22.3, 95% CI: 6.3, 78.1), severe initial rheumatic involvement (adjusted OR: 5.5, 95% CI: 2.2, 13.8) and CHIKV-specific IgG titres (adjusted OR: 6.2, 95% CI: 2.8, 13.2, per one unit increase). CHIKV specific IgG titres were positively correlated with age, female gender and the severity of initial rheumatic symptoms. CONCLUSIONS: Our data support the roles of age, severity at presentation and CHIKV specific IgG titres for predicting CHIK-R. By identifying the prognostic value of the humoral immune response of the host, this work also suggest a significant contribution of the adaptive immune response to the physiopathology of CHIK-R and should help to reconsider the paradigm of this chronic infection primarily shifted towards the involvement of the innate immune response.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 2 1%
Germany 1 <1%
Unknown 141 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 14%
Researcher 16 11%
Student > Master 16 11%
Student > Bachelor 15 10%
Other 14 10%
Other 30 21%
Unknown 34 23%
Readers by discipline Count As %
Medicine and Dentistry 41 28%
Agricultural and Biological Sciences 22 15%
Immunology and Microbiology 13 9%
Nursing and Health Professions 10 7%
Biochemistry, Genetics and Molecular Biology 8 5%
Other 15 10%
Unknown 37 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2019.
All research outputs
#1,831,708
of 20,328,176 outputs
Outputs from Arthritis Research & Therapy
#349
of 2,778 outputs
Outputs of similar age
#19,886
of 202,282 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 4 outputs
Altmetric has tracked 20,328,176 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,778 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them