Title |
No evidence for copy number and methylation variation in H19 and KCNQ10T1 imprinting control regions in children born small for gestational age
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Published in |
BMC Medical Genomics, June 2014
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DOI | 10.1186/1471-2350-15-67 |
Pubmed ID | |
Authors |
Rinki Murphy, John MD Thompson, Jörg Tost, Edwin A Mitchell |
Abstract |
There is a substantial genetic component for birthweight variation, and although there are known associations between fetal genotype and birthweight, the role of common epigenetic variation in influencing the risk for small for gestational age (SGA) is unknown. The two imprinting control regions (ICRs) located on chromosome 11p15.5, involved in the overgrowth disorder Beckwith-Wiedemann syndrome (BWS) and the growth restriction disorder Silver-Russell syndrome (SRS), are prime epigenetic candidates for regulating fetal growth. We investigated whether common variation in copy number in the BWS/SRS 11p15 region or altered methylation levels at IGF2/H19 ICR or KCNQ10T1 ICR was associated with SGA. |
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Mendeley readers
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Student > Master | 5 | 14% |
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Other | 3 | 8% |
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