Title |
Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome
|
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Published in |
Journal of Neuroinflammation, June 2014
|
DOI | 10.1186/1742-2094-11-110 |
Pubmed ID | |
Authors |
Milo Careaga, Tamanna Noyon, Kirin Basuta, Judy Van de Water, Flora Tassone, Randi J Hagerman, Paul Ashwood |
Abstract |
Fragile X syndrome (FXS) is the leading cause of inheritable intellectual disability in male children, and is predominantly caused by a single gene mutation resulting in expanded trinucleotide CGG-repeats within the 5' untranslated region of the fragile X mental retardation (FMR1) gene. Reports have suggested the presence of immune dysregulation in FXS with evidence of altered plasma cytokine levels; however, no studies have directly assessed functional cellular immune responses in children with FXS. In order to ascertain if immune dysregulation is present in children with FXS, dynamic cellular responses to immune stimulation were examined. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 16% |
Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 6 | 13% |
Student > Master | 5 | 11% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 16% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 8 | 18% |
Psychology | 6 | 13% |
Agricultural and Biological Sciences | 4 | 9% |
Medicine and Dentistry | 4 | 9% |
Nursing and Health Professions | 2 | 4% |
Other | 8 | 18% |
Unknown | 13 | 29% |