Title |
The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial
|
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Published in |
Trials, June 2014
|
DOI | 10.1186/1745-6215-15-218 |
Pubmed ID | |
Authors |
David J Klein, Debra Foster, Christa A Schorr, Kazem Kazempour, Paul M Walker, R Phillip Dellinger |
Abstract |
Septic shock is common and has unacceptably high morbidity, mortality, and associated cost with numerous failed attempts at developing effective therapies. Endotoxin, one of the most potent mediators of sepsis, is found in high levels in approximately 50% of patients with septic shock. Polymyxin B (PMX) hemoperfusion has been shown in numerous studies to successfully remove endotoxin and potentially improve outcomes. EUPHRATES (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock) is a theragnostic trial (matching blood measurement to treatment capability) of PMX hemoperfusion in patients with septic shock and confirmed endotoxemia as measured by the endotoxin activity assay (EAA). |
X Demographics
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Country | Count | As % |
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United Kingdom | 5 | 28% |
Canada | 2 | 11% |
Switzerland | 1 | 6% |
Australia | 1 | 6% |
Saudi Arabia | 1 | 6% |
Unknown | 8 | 44% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 14 | 78% |
Scientists | 3 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
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Italy | 2 | 2% |
Unknown | 97 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 22% |
Student > Master | 14 | 14% |
Student > Ph. D. Student | 9 | 9% |
Student > Postgraduate | 9 | 9% |
Other | 8 | 8% |
Other | 18 | 18% |
Unknown | 19 | 19% |
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Medicine and Dentistry | 50 | 51% |
Nursing and Health Professions | 8 | 8% |
Agricultural and Biological Sciences | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Engineering | 2 | 2% |
Other | 6 | 6% |
Unknown | 23 | 23% |