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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic regulation of caloric restriction in aging
|
|---|---|
| Published in |
BMC Medicine, August 2011
|
| DOI | 10.1186/1741-7015-9-98 |
| Pubmed ID | |
| Authors |
Yuanyuan Li, Michael Daniel, Trygve O Tollefsbol |
| Abstract |
The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 25% |
| Mexico | 1 | 8% |
| Spain | 1 | 8% |
| Unknown | 7 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 67% |
| Scientists | 3 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 374 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 2% |
| Spain | 3 | <1% |
| Mexico | 3 | <1% |
| Italy | 2 | <1% |
| Japan | 2 | <1% |
| Australia | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 346 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 66 | 18% |
| Student > Ph. D. Student | 59 | 16% |
| Student > Bachelor | 52 | 14% |
| Student > Master | 49 | 13% |
| Professor > Associate Professor | 22 | 6% |
| Other | 78 | 21% |
| Unknown | 48 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 106 | 28% |
| Biochemistry, Genetics and Molecular Biology | 85 | 23% |
| Medicine and Dentistry | 54 | 14% |
| Neuroscience | 13 | 3% |
| Psychology | 9 | 2% |
| Other | 44 | 12% |
| Unknown | 63 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2023.
All research outputs
#1,280,806
of 24,447,003 outputs
Outputs from BMC Medicine
#895
of 3,775 outputs
Outputs of similar age
#5,447
of 127,349 outputs
Outputs of similar age from BMC Medicine
#8
of 27 outputs
Altmetric has tracked 24,447,003 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,775 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,349 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.