Title |
Fecal carriage of extended-spectrum β-lactamases and AmpC-producing Escherichia coli in a Libyan community
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Published in |
Annals of Clinical Microbiology and Antimicrobials, June 2014
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DOI | 10.1186/1476-0711-13-22 |
Pubmed ID | |
Authors |
Salwa Fouad Ahmed, Mostafa Mohamed M Ali, Zienat Kamel Mohamed, Tarek A Moussa, John D Klena |
Abstract |
Extended-spectrum beta-lactamases (ESBLs), including the AmpC type, are important mechanisms of resistance among Enterobacteriaeceae. CTX-M type extended-spectrum beta- lactamases, of which there are now over 90 variants, are distributed globally, yet appear to vary in regional distribution. AmpC beta-lactamases hydrolyze third generation cephalosporins, but are resistant to inhibition by clavulanate or other beta-lactamase inhibitors in vitro. Fecal carriage and rates of colonization by bacteria harboring these resistance mechanisms have been reported in patients with community-acquired infections and in healthy members of their households. Expression of these ESBLs compromises the efficacy of current antibacterial therapies, potentially increasing the seriousness of hospital- and community-acquired Escherichia coli (E. coli) infections.To investigate the occurrence of ESBL-producing E. coli in human fecal flora isolated from two pediatric populations residing in the Libyan cities Zleiten and Abou El Khoms. Isolates were further studied to characterize genes encoding beta-lactam resistance, and establish genetic relationships. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
France | 2 | 2% |
Unknown | 114 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 16% |
Student > Ph. D. Student | 15 | 13% |
Researcher | 14 | 12% |
Student > Bachelor | 11 | 9% |
Student > Postgraduate | 11 | 9% |
Other | 30 | 25% |
Unknown | 18 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 25% |
Immunology and Microbiology | 18 | 15% |
Biochemistry, Genetics and Molecular Biology | 14 | 12% |
Agricultural and Biological Sciences | 13 | 11% |
Nursing and Health Professions | 3 | 3% |
Other | 14 | 12% |
Unknown | 27 | 23% |