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The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

Overview of attention for article published in Journal of Translational Medicine, January 2014
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1 tweeter

Citations

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36 Mendeley
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Title
The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients
Published in
Journal of Translational Medicine, January 2014
DOI 10.1186/1479-5876-12-177
Pubmed ID
Authors

Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer, José Hinz

Abstract

Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS plays a major role in sepsis pathogenesis. A single nucleotide polymorphism, rs11536889, in the 3'-untranslated region of the TLR4 gene is thought to affect TLR4 translation. This study aimed to investigate whether organ failure in sepsis patients is related to the TLR4 rs11536889 genotype.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ukraine 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 22%
Student > Ph. D. Student 7 19%
Student > Bachelor 6 17%
Student > Doctoral Student 4 11%
Researcher 3 8%
Other 3 8%
Unknown 5 14%
Readers by discipline Count As %
Medicine and Dentistry 12 33%
Immunology and Microbiology 8 22%
Agricultural and Biological Sciences 6 17%
Biochemistry, Genetics and Molecular Biology 2 6%
Psychology 2 6%
Other 1 3%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2014.
All research outputs
#20,231,820
of 22,757,541 outputs
Outputs from Journal of Translational Medicine
#3,306
of 3,978 outputs
Outputs of similar age
#264,795
of 305,260 outputs
Outputs of similar age from Journal of Translational Medicine
#77
of 114 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,978 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,260 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.