Title |
Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection
|
---|---|
Published in |
Critical Care, June 2014
|
DOI | 10.1186/cc13934 |
Pubmed ID | |
Authors |
Estefanía Herrera-Ramos, Marta López-Rodríguez, José Juan Ruíz-Hernández, Juan Pablo Horcajada, Luis Borderías, Elisabeth Lerma, José Blanquer, María Carmen Pérez-González, María Isabel García-Laorden, Yanira Florido, Virginia Mas-Bosch, Milagro Montero, José María Ferrer, Luisa Sorlí, Carlos Vilaplana, Olga Rajas, Marisa Briones, Javier Aspa, Eduardo López-Granados, Jordi Solé-Violán, Felipe Rodríguez de Castro, Carlos Rodríguez-Gallego |
Abstract |
Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components of the innate immune response may be crucial in the first days of the infection. The collectins surfactant protein (SP)-A1, -A2, and -D and mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can establish an efficient neutralization of poorly glycosylated pandemic IAV strains. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Greece | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 2% |
Unknown | 55 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 18% |
Student > Ph. D. Student | 6 | 11% |
Professor > Associate Professor | 5 | 9% |
Student > Bachelor | 5 | 9% |
Student > Master | 5 | 9% |
Other | 18 | 32% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 38% |
Agricultural and Biological Sciences | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Nursing and Health Professions | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 5 | 9% |
Unknown | 10 | 18% |