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Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer

Overview of attention for article published in BMC Systems Biology, June 2014
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Title
Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer
Published in
BMC Systems Biology, June 2014
DOI 10.1186/1752-0509-8-72
Pubmed ID
Authors

Jean-Eudes J Dazard, Yana Sandlers, Stephanie K Doerner, Nathan A Berger, Henri Brunengraber

Abstract

To determine how diets high in saturated fat could increase polyp formation in the mouse model of intestinal neoplasia, ApcMin/+, we conducted large-scale metabolome analysis and association study of colon and small intestine polyp formation from plasma and liver samples of ApcMin/+ vs. wild-type littermates, kept on low vs. high-fat diet. Label-free mass spectrometry was used to quantify untargeted plasma and acyl-CoA liver compounds, respectively. Differences in contrasts of interest were analyzed statistically by unsupervised and supervised modeling approaches, namely Principal Component Analysis and Linear Model of analysis of variance. Correlation between plasma metabolite concentrations and polyp numbers was analyzed with a zero-inflated Generalized Linear Model.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Germany 1 2%
Brazil 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 22%
Researcher 7 17%
Student > Master 6 15%
Student > Bachelor 5 12%
Lecturer 4 10%
Other 7 17%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 34%
Biochemistry, Genetics and Molecular Biology 6 15%
Medicine and Dentistry 5 12%
Engineering 4 10%
Computer Science 2 5%
Other 4 10%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2014.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from BMC Systems Biology
#651
of 1,132 outputs
Outputs of similar age
#146,835
of 243,358 outputs
Outputs of similar age from BMC Systems Biology
#14
of 26 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,132 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,358 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.