Title |
High dose of tigecycline for extremely resistant Gram-negative pneumonia: yes, we can
|
---|---|
Published in |
Critical Care, June 2014
|
DOI | 10.1186/cc13942 |
Pubmed ID | |
Authors |
José Garnacho-Montero, Carmen Ferrándiz-Millón |
Abstract |
Few antimicrobials are currently active to treat infections caused by extremely resistant Gram-negative bacilli (ERGNB), which represent a serious global public health concern. Tigecycline, which covers the majority of these ERGNB (with the exception of Pseudomonas aeruginosa), is not currently approved for hospital-acquired pneumonia, and several meta-analyses have suggested an increased risk of death in patients receiving this antibiotic. Other studies suggest that the use of high-dose tigecycline may represent an alternative in daily practice. De Pascale and colleagues report that the clinical cure rate in patients with ventilator-associated pneumonia is significantly higher with a high dose of tigecycline than with the conventional dose, although mortality was unaffected. This high dose is safe; no patients required discontinuation or dose reduction. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
France | 1 | 3% |
Unknown | 30 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 19% |
Student > Postgraduate | 5 | 16% |
Other | 4 | 13% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 3 | 9% |
Other | 2 | 6% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 56% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 22% |