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The protective immune response produced in dogs after primary vaccination with the LiESP/QA-21 vaccine (CaniLeish®) remains effective against an experimental challenge one year later

Overview of attention for article published in Veterinary Research, June 2014
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Title
The protective immune response produced in dogs after primary vaccination with the LiESP/QA-21 vaccine (CaniLeish®) remains effective against an experimental challenge one year later
Published in
Veterinary Research, June 2014
DOI 10.1186/1297-9716-45-69
Pubmed ID
Authors

Virginie Martin, Ioannis Vouldoukis, Javier Moreno, David McGahie, Sylvie Gueguen, Anne-Marie Cuisinier

Abstract

Control of canine leishmaniasis is an important objective for the benefit of dogs living in or visiting endemic areas and for public health because of the zoonotic nature of this disease. Resistance or susceptibility to developing canine leishmaniasis after exposure to Leishmania infantum is primarily determined by the ability of the immune system to develop an appropriate Th1-dominated specific response to the parasite. For this reason there is a need for effective canine vaccines that can decrease the number of dogs developing progressive infections. In this study, we followed the impact of the LiESP/QA-21 canine vaccine (composed of excreted-secreted proteins of L. infantum and the QA-21 saponin adjuvant), recently launched commercially in Europe, on selected humoral and cellular immune parameters following an infectious intravenous challenge with L. infantum promastigotes administered one year after the primary vaccine course. We also followed parasitological parameters to determine the parasitological status of the challenged dogs. In contrast to controls, vaccinated dogs retained significantly stronger cell-mediated immune responses against the parasite despite a virulent challenge and had significantly lower mean parasite burdens at the end of the study, associated with a lower probability of developing active infections. These results confirm that the immune responses generated by vaccination with LiESP/QA-21 are still effective against an intravenous challenge one year after the primary vaccine course.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 3%
Brazil 2 2%
France 1 <1%
Portugal 1 <1%
Unknown 102 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 24%
Student > Ph. D. Student 15 14%
Student > Bachelor 9 8%
Student > Doctoral Student 8 7%
Researcher 8 7%
Other 17 16%
Unknown 26 24%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 23 21%
Agricultural and Biological Sciences 17 16%
Biochemistry, Genetics and Molecular Biology 12 11%
Medicine and Dentistry 10 9%
Immunology and Microbiology 6 6%
Other 12 11%
Unknown 29 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2014.
All research outputs
#17,290,421
of 25,389,116 outputs
Outputs from Veterinary Research
#827
of 1,323 outputs
Outputs of similar age
#143,045
of 238,565 outputs
Outputs of similar age from Veterinary Research
#14
of 24 outputs
Altmetric has tracked 25,389,116 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,323 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,565 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.