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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
|
|---|---|
| Published in |
BMC Neuroscience, December 2008
|
| DOI | 10.1186/1471-2202-9-s3-s5 |
| Pubmed ID | |
| Authors |
Leah R Hanson, William H Frey |
| Abstract |
Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic administration and its potential side effects. This is possible because of the unique connections that the olfactory and trigeminal nerves provide between the brain and external environment. Intranasal delivery does not necessarily require any modification to therapeutic agents. A wide variety of therapeutics, including both small molecules and macromolecules, can be targeted to the olfactory system and connected memory areas affected by Alzheimer's disease. Using the intranasal delivery system, researchers have reversed neurodegeneration and rescued memory in a transgenic mouse model of Alzheimer's disease. Intranasal insulin-like growth factor-I, deferoxamine, and erythropoietin have been shown to protect the brain against stroke in animal models. Intranasal delivery has been used to target the neuroprotective peptide NAP to the brain to treat neurodegeneration. Intranasal fibroblast growth factor-2 and epidermal growth factor have been shown to stimulate neurogenesis in adult animals. Intranasal insulin improves memory, attention, and functioning in patients with Alzheimer's disease or mild cognitive impairment, and even improves memory and mood in normal adult humans. This new method of delivery can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| South Africa | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 540 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Canada | 2 | <1% |
| Germany | 1 | <1% |
| Pakistan | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 526 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 104 | 19% |
| Researcher | 82 | 15% |
| Student > Master | 57 | 11% |
| Student > Bachelor | 50 | 9% |
| Student > Doctoral Student | 25 | 5% |
| Other | 91 | 17% |
| Unknown | 131 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 16% |
| Medicine and Dentistry | 78 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 52 | 10% |
| Neuroscience | 52 | 10% |
| Biochemistry, Genetics and Molecular Biology | 32 | 6% |
| Other | 82 | 15% |
| Unknown | 159 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#1,408,704
of 25,056,530 outputs
Outputs from BMC Neuroscience
#28
of 1,288 outputs
Outputs of similar age
#5,328
of 179,785 outputs
Outputs of similar age from BMC Neuroscience
#3
of 20 outputs
Altmetric has tracked 25,056,530 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,288 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,785 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.