Title |
Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39
|
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Published in |
BMC Medical Genomics, June 2014
|
DOI | 10.1186/1471-2350-15-73 |
Pubmed ID | |
Authors |
Rossella Melchiotti, Kia Joo Puan, Anand Kumar Andiappan, Tuang Yeow Poh, Mireille Starke, Li Zhuang, Kerstin Petsch, Tuck Siong Lai, Fook Tim Chew, Anis Larbi, De Yun Wang, Michael Poidinger, Olaf Rotzschke |
Abstract |
Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages in diseases such as multiple sclerosis, Hepatitis B and HIV-1. In addition, CD39 polymorphisms have been implicated in immune-phenotypes such as susceptibility to inflammatory bowel disease and AIDS progression. However none of the studies published so far has linked disease-associated variants with differences in CD39 Treg surface expression. This study aims at identifying variants affecting CD39 expression on Treg and at evaluating their association with allergic rhinitis, a disease characterized by a strong Treg involvement. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 19% |
Student > Ph. D. Student | 7 | 12% |
Student > Master | 7 | 12% |
Student > Bachelor | 6 | 11% |
Other | 4 | 7% |
Other | 6 | 11% |
Unknown | 16 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Immunology and Microbiology | 5 | 9% |
Neuroscience | 2 | 4% |
Other | 6 | 11% |
Unknown | 19 | 33% |