Title |
Distribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7
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Published in |
BMC Genomics, June 2014
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DOI | 10.1186/1471-2164-15-537 |
Pubmed ID | |
Authors |
Grit Ebert, Anne Steininger, Robert Weißmann, Vivien Boldt, Allan Lind-Thomsen, Jana Grune, Stefan Badelt, Melanie Heßler, Matthias Peiser, Manuel Hitzler, Lars R Jensen, Ines Müller, Hao Hu, Peter F Arndt, Andreas W Kuss, Katrin Tebel, Reinhard Ullmann |
Abstract |
Segmental duplications (SDs) are not evenly distributed along chromosomes. The reasons for this biased susceptibility to SD insertion are poorly understood. Accumulation of SDs is associated with increased genomic instability, which can lead to structural variants and genomic disorders such as the Williams-Beuren syndrome. Despite these adverse effects, SDs have become fixed in the human genome. Focusing on chromosome 7, which is particularly rich in interstitial SDs, we have investigated the distribution of SDs in the context of evolution and the three dimensional organisation of the chromosome in order to gain insights into the mutual relationship of SDs and chromatin topology. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 2% |
Lithuania | 1 | 2% |
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Philippines | 1 | 2% |
Unknown | 36 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 22% |
Student > Doctoral Student | 6 | 15% |
Researcher | 6 | 15% |
Student > Master | 5 | 12% |
Student > Bachelor | 4 | 10% |
Other | 7 | 17% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 39% |
Biochemistry, Genetics and Molecular Biology | 13 | 32% |
Medicine and Dentistry | 4 | 10% |
Immunology and Microbiology | 1 | 2% |
Psychology | 1 | 2% |
Other | 1 | 2% |
Unknown | 5 | 12% |