Title |
Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function
|
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Published in |
BMC Molecular and Cell Biology, June 2014
|
DOI | 10.1186/1471-2121-15-24 |
Pubmed ID | |
Authors |
Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath, Baggavalli P Somesh |
Abstract |
Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-cells. The G protein coupled receptor 40 (GPR40) is implicated for glucose induced insulin secretion. We hypothesized that GPR40 activation can protect β-cells from inflammation-induced apoptosis and restore glucose stimulated insulin secretion. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 17% |
Student > Bachelor | 6 | 15% |
Student > Ph. D. Student | 6 | 15% |
Student > Master | 5 | 12% |
Unspecified | 4 | 10% |
Other | 7 | 17% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
Medicine and Dentistry | 5 | 12% |
Unspecified | 4 | 10% |
Chemistry | 4 | 10% |
Other | 9 | 22% |
Unknown | 6 | 15% |