Title |
Insulator function and topological domain border strength scale with architectural protein occupancy
|
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Published in |
Genome Biology, June 2014
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DOI | 10.1186/gb-2014-15-5-r82 |
Pubmed ID | |
Authors |
Kevin Van Bortle, Michael H Nichols, Li Li, Chin-Tong Ong, Naomi Takenaka, Zhaohui S Qin, Victor G Corces |
Abstract |
Chromosome conformation capture studies suggest that eukaryotic genomes are organized into structures called topologically associating domains. The borders of these domains are highly enriched for architectural proteins with characterized roles in insulator function. However, a majority of architectural protein binding sites localize within topological domains, suggesting sites associated with domain borders represent a functionally different subclass of these regulatory elements. How topologically associating domains are established and what differentiates border-associated from non-border architectural protein binding sites remain unanswered questions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
United Kingdom | 2 | 33% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
United Kingdom | 4 | 1% |
China | 2 | <1% |
Germany | 2 | <1% |
France | 2 | <1% |
Korea, Republic of | 1 | <1% |
Hungary | 1 | <1% |
Denmark | 1 | <1% |
Netherlands | 1 | <1% |
Other | 2 | <1% |
Unknown | 303 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 98 | 30% |
Researcher | 57 | 18% |
Student > Master | 34 | 10% |
Student > Bachelor | 30 | 9% |
Student > Doctoral Student | 16 | 5% |
Other | 37 | 11% |
Unknown | 52 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 125 | 39% |
Biochemistry, Genetics and Molecular Biology | 123 | 38% |
Computer Science | 9 | 3% |
Physics and Astronomy | 5 | 2% |
Mathematics | 2 | <1% |
Other | 9 | 3% |
Unknown | 51 | 16% |