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Induction of inflammatory cytokines and toll-like receptors in chickens infected with avian H9N2 influenza virus

Overview of attention for article published in Veterinary Research, May 2011
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Title
Induction of inflammatory cytokines and toll-like receptors in chickens infected with avian H9N2 influenza virus
Published in
Veterinary Research, May 2011
DOI 10.1186/1297-9716-42-64
Pubmed ID
Authors

Nguyen Tai Nang, Joo Sub Lee, Byung Min Song, Young Myong Kang, Hyun Soo Kim, Sang Heui Seo

Abstract

H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited. Here, we show that H9N2 induces pro-inflammatory cytokines such as transforming growth factor-beta 3; tumor necrosis factor-alpha; interferon-alpha, -beta, and gamma; and TLR 1, 2, 3, 4, 5, 7, and 15 in trachea, lung, and intestine of infected chickens. In the lung, TLR-15 was dominantly induced. Taken together, it seems that H9N2 infections efficiently induce inflammatory cytokines and TLRs in trachea, lung and intestine of chickens.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 12 27%
Student > Master 4 9%
Student > Doctoral Student 2 4%
Professor 2 4%
Other 5 11%
Unknown 8 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 36%
Veterinary Science and Veterinary Medicine 7 16%
Immunology and Microbiology 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Medicine and Dentistry 4 9%
Other 1 2%
Unknown 8 18%