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Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders

Overview of attention for article published in Molecular Autism, July 2014
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Title
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders
Published in
Molecular Autism, July 2014
DOI 10.1186/2040-2392-5-38
Pubmed ID
Authors

Hendrik Wesseling, Paul C Guest, Chi-Ming Lee, Erik HF Wong, Hassan Rahmoune, Sabine Bahn

Abstract

Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1(neo-/-)) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now revealed that the model also recapitulates cognitive and negative symptoms in the continuum of other psychiatric diseases, particularly autism spectrum disorders (ASD). As previous studies have mostly focussed on behavioural readouts, a molecular characterisation of this model will help to identify novel biomarkers or potential drug targets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Canada 1 <1%
Unknown 123 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 17%
Student > Ph. D. Student 17 13%
Student > Bachelor 15 12%
Student > Master 14 11%
Student > Doctoral Student 7 6%
Other 24 19%
Unknown 28 22%
Readers by discipline Count As %
Neuroscience 22 17%
Agricultural and Biological Sciences 17 13%
Medicine and Dentistry 16 13%
Biochemistry, Genetics and Molecular Biology 14 11%
Psychology 8 6%
Other 15 12%
Unknown 34 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2014.
All research outputs
#14,782,376
of 22,758,248 outputs
Outputs from Molecular Autism
#593
of 666 outputs
Outputs of similar age
#126,712
of 227,393 outputs
Outputs of similar age from Molecular Autism
#6
of 7 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 666 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,393 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.