Title |
Regulation of a LATS-homolog by Ras GTPases is important for the control of cell division
|
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Published in |
BMC Molecular and Cell Biology, July 2014
|
DOI | 10.1186/1471-2121-15-25 |
Pubmed ID | |
Authors |
Annette Müller-Taubenberger, Peter M Kastner, Michael Schleicher, Parvin Bolourani, Gerald Weeks |
Abstract |
Nuclear Dbf-related/large tumor suppressor (NDR/LATS) kinases have been shown recently to control pathways that regulate mitotic exit, cytokinesis, cell growth, morphological changes and apoptosis. LATS kinases are core components of the Hippo signaling cascade and important tumor suppressors controlling cell proliferation and organ size in flies and mammals, and homologs are also present in yeast and Dictyostelium discoideum. Ras proto-oncogens regulate many biological functions, including differentiation, proliferation and apoptosis. Dysfunctions of LATS kinases or Ras GTPases have been implicated in the development of a variety of cancers in humans. |
X Demographics
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Canada | 1 | 4% |
Unknown | 22 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 25% |
Professor > Associate Professor | 5 | 21% |
Student > Ph. D. Student | 4 | 17% |
Other | 2 | 8% |
Student > Master | 2 | 8% |
Other | 3 | 13% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 50% |
Biochemistry, Genetics and Molecular Biology | 7 | 29% |
Computer Science | 1 | 4% |
Physics and Astronomy | 1 | 4% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 2 | 8% |