This Clinical Trial started in 2012. Wtf. A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome - PMC https://t.co/FxkAoHtnuW
5,170 followers
2,251 followers
@CMichaelGibson Interesting. There are currently recombinant ACE2 infusion trials in ARDS (https://t.co/uE1ASfYMts) and pulmonary hypertension (https://t.co/5ABKDYkbf4). May be worth a proof of principle study.
8,018 followers
at the doses used in the 2017 ARDS study: 'The lack of improvement in oxygenation in patients receiving GSK2586881 contrasts with effects reported in large animal models of ARDS where IV rhACE2 rapidly improved arterial hypoxemia & pulmonary hemodynam
1,635 followers
Big questions about what the effects of this compound would be on the renin-angiotensin system in vivo, although note it has had reassuring results in phase I/II studies in healthy volunteers & patients with ARDS https://t.co/OrfkWzgwXK & https://t