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Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature

Overview of attention for article published in BMC Urology, September 2017
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Title
Extranodal nasal-type natural killer/T-cell lymphoma with penile involvement: a case report and review of the literature
Published in
BMC Urology, September 2017
DOI 10.1186/s12894-017-0273-8
Pubmed ID
Authors

Xiaotian Wang, Zimu Gong, Shawn Xiang Li, Wei Yan, Yongsheng Song

Abstract

Extranodal natural killer/T-cell lymphoma (ENKTL) usually presents as a localized disease in the nasal cavity; extension to the male genitourinary system is very rare and has been characterized only recently. Most cases present with predominantly extranodal involvement, advanced stage disease, highly aggressive course, and strong association with Epstein-Barr virus (EBV). While metastasis is common in ENKTLs, the penis is rarely involved in both nasal and non-nasal ENKTLs and only one report was published to date. One patient with NK/T-cell lymphoma, presented initially with a penile mass, is reported. The 58-year-old man who presented with progressive painless penile swelling underwent penectomy for penile tumor. Histologically, the glans and foreskin revealed neoplastic infiltration of medium-sized lymphoma cells expressing CD56, CD3, granzyme-B, and labeled for EBV-encoded RNA in situ hybridization. Findings were consistent with NK/T-cell lymphoma. By detailed history, we learned that the patient had nasal obstruction for more than 10 years. Nasopharyngeal involvement was screened with PET-CT; ENKTL was diagnosed after a nasopharyngeal biopsy. The final diagnosis was primary nasal NK/T-cell lymphoma, with metastasis to the penis. Additional sites of disease appeared soon afterward (adrenal gland, liver, spleen and lymph nodes). The patient died within 4 months. This study suggested that penile NK/T-cell lymphoma tends to disseminate early and pursues an aggressive course. It is imperative to distinguish nasal NK/T lymphoma from other types of tumors, because the prognosis and treatment differ significantly for secondary metastases.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 27%
Researcher 6 23%
Student > Bachelor 3 12%
Student > Doctoral Student 2 8%
Unspecified 1 4%
Other 2 8%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 16 62%
Nursing and Health Professions 2 8%
Immunology and Microbiology 1 4%
Unspecified 1 4%
Unknown 6 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2017.
All research outputs
#20,446,373
of 23,001,641 outputs
Outputs from BMC Urology
#652
of 754 outputs
Outputs of similar age
#275,645
of 315,600 outputs
Outputs of similar age from BMC Urology
#15
of 20 outputs
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