Title |
A randomized, phase III trial of capecitabine plus bevacizumab (Cape-Bev) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI-Bev) in first-line treatment of metastatic colorectal cancer: The AIO KRK 0110 Trial/ML22011 Trial
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Published in |
BMC Cancer, August 2011
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DOI | 10.1186/1471-2407-11-367 |
Pubmed ID | |
Authors |
Clemens Giessen, Ludwig Fischer von Weikersthal, Axel Hinke, Sebastian Stintzing, Frank Kullmann, Ursula Vehling-Kaiser, Julia Mayerle, Markus Bangerter, Claudio Denzlinger, Markus Sieber, Christian Teschendorf, Jens Freiberg-Richter, Christoph Schulz, Dominik Paul Modest, Nicolas Moosmann, Philipp Aubele, Volker Heinemann |
Abstract |
Several randomized trials have indicated that combination chemotherapy applied in metastatic colorectal cancer (mCRC) does not significantly improve overall survival when compared to the sequential use of cytotoxic agents (CAIRO, MRC Focus, FFCD 2000-05). The present study investigates the question whether this statement holds true also for bevacizumab-based first-line treatment including escalation- and de-escalation strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ecuador | 1 | 1% |
Unknown | 66 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 22% |
Student > Master | 7 | 10% |
Other | 6 | 9% |
Student > Bachelor | 6 | 9% |
Student > Ph. D. Student | 4 | 6% |
Other | 11 | 16% |
Unknown | 18 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 35 | 52% |
Engineering | 3 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Neuroscience | 2 | 3% |
Business, Management and Accounting | 1 | 1% |
Other | 6 | 9% |
Unknown | 18 | 27% |