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The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis

Overview of attention for article published in Reproductive Biology and Endocrinology, July 2014
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Title
The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis
Published in
Reproductive Biology and Endocrinology, July 2014
DOI 10.1186/1477-7827-12-60
Pubmed ID
Authors

Megan M Emori, Ronny Drapkin

Abstract

Ovulation has long been associated with an increased risk in ovarian cancer, yet the underlying molecular mechanisms remain obscure. Two aspects of ovulation have been linked to ovarian cancer pathogenesis. The first is the impact of repetitive tissue injury and repair that occurs with each ovulatory event. The second is the release of follicular fluid that accompanies the follicular rupture and its effect on the ovarian and fallopian tube epithelial cells. Hormones are an important component of follicular fluid, which transiently bathes the ovarian surface and fallopian tube epithelium during ovulation. Much work has been done exploring the role of hormones in fertility, but some, such as estrogen, have also been implicated in the pathogenesis of ovarian and other cancers. Understanding the role of hormones within follicular fluid, as well as how they are altered in disorders which increase ovarian cancer risk, will enhance our ability to assess risk and develop preventative strategies. This review provides an in depth discussion of the logistics of using and studying follicular fluid in ovarian cancer research, and discusses the fluctuations in follicular fluid hormone levels during normal physiological processes versus conditions that increase ovarian cancer risk.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
United States 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Student > Master 11 14%
Student > Bachelor 7 9%
Researcher 5 6%
Professor > Associate Professor 4 5%
Other 12 16%
Unknown 21 27%
Readers by discipline Count As %
Medicine and Dentistry 20 26%
Agricultural and Biological Sciences 16 21%
Biochemistry, Genetics and Molecular Biology 10 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Veterinary Science and Veterinary Medicine 1 1%
Other 4 5%
Unknown 24 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2014.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Reproductive Biology and Endocrinology
#774
of 1,134 outputs
Outputs of similar age
#177,877
of 242,372 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#8
of 15 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,134 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,372 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.