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Mendeley readers
Attention Score in Context
| Title |
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
|
|---|---|
| Published in |
Journal of Neuroinflammation, May 2011
|
| DOI | 10.1186/1742-2094-8-50 |
| Pubmed ID | |
| Authors |
Carol L Murray, Donal T Skelly, Colm Cunningham |
| Abstract |
Chronic neurodegeneration comprises an inflammatory response but its contribution to the progression of disease remains unclear. We have previously shown that microglial cells are primed by chronic neurodegeneration, induced by the ME7 strain of prion disease, to synthesize limited pro-inflammatory cytokines but to produce exaggerated responses to subsequent systemic inflammatory insults. The consequences of this primed response include exaggerated hypothermic and sickness behavioural responses, acute neuronal death and accelerated progression of disease. Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses. |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 134 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 24% |
| Researcher | 19 | 14% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 27 | 20% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 27% |
| Neuroscience | 29 | 21% |
| Medicine and Dentistry | 21 | 15% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Psychology | 3 | 2% |
| Other | 10 | 7% |
| Unknown | 26 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2014.
All research outputs
#2,933,225
of 22,758,248 outputs
Outputs from Journal of Neuroinflammation
#506
of 2,619 outputs
Outputs of similar age
#14,281
of 111,909 outputs
Outputs of similar age from Journal of Neuroinflammation
#2
of 13 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.