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Mendeley readers
Attention Score in Context
Title |
Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
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Published in |
Molecular Neurodegeneration, July 2014
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DOI | 10.1186/1750-1326-9-27 |
Pubmed ID | |
Authors |
Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein |
Abstract |
The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and pathologically in Parkinson's disease (PD). Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export. We previously showed that ceruloplasmin knockout (CP KO) mice exhibit Parkinsonian neurodegeneration (~30% nigral loss) by 6 months, which is prevented by iron chelation. Here, we explored whether known iron-stressors of the SN (1) aging and (2) MPTP, would exaggerate the lesion severity of CP KO mice. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 2% |
Germany | 1 | 2% |
Australia | 1 | 2% |
Unknown | 47 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Researcher | 8 | 16% |
Student > Master | 7 | 14% |
Student > Bachelor | 5 | 10% |
Other | 5 | 10% |
Other | 10 | 20% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 24% |
Neuroscience | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Chemistry | 4 | 8% |
Other | 10 | 20% |
Unknown | 7 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2014.
All research outputs
#15,302,478
of 22,758,248 outputs
Outputs from Molecular Neurodegeneration
#715
of 846 outputs
Outputs of similar age
#131,375
of 225,815 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 10 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 846 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,815 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.