Title |
Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage
|
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Published in |
Genome Biology, August 2011
|
DOI | 10.1186/gb-2011-12-8-r77 |
Pubmed ID | |
Authors |
Min Zhu, Ming Yi, Chang Hee Kim, Chuxia Deng, Yi Li, Daniel Medina, Robert M Stephens, Jeffrey E Green |
Abstract |
MicroRNAs (miRNAs) are small, non-coding, endogenous RNAs involved in regulating gene expression and protein translation. miRNA expression profiling of human breast cancers has identified miRNAs related to the clinical diversity of the disease and potentially provides novel diagnostic and prognostic tools for breast cancer therapy. In order to further understand the associations between oncogenic drivers and miRNA expression in sub-types of breast cancer, we performed miRNA expression profiling on mammary tumors from eight well-characterized genetically engineered mouse (GEM) models of human breast cancer, including MMTV-H-Ras, -Her2/neu, -c-Myc, -PymT, -Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1(fl/fl);p53(+/-);MMTV-cre knock-out mice and the p53(fl/fl);MMTV-cre transplant model. |
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United States | 2 | 2% |
United Kingdom | 2 | 2% |
Australia | 1 | <1% |
Finland | 1 | <1% |
Norway | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Denmark | 1 | <1% |
Other | 1 | <1% |
Unknown | 102 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 37 | 32% |
Student > Ph. D. Student | 28 | 24% |
Student > Master | 10 | 9% |
Professor > Associate Professor | 7 | 6% |
Student > Bachelor | 5 | 4% |
Other | 16 | 14% |
Unknown | 12 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 63 | 55% |
Biochemistry, Genetics and Molecular Biology | 18 | 16% |
Medicine and Dentistry | 6 | 5% |
Computer Science | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 8 | 7% |
Unknown | 13 | 11% |