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Roles of CXCL5 on migration and invasion of liver cancer cells

Overview of attention for article published in Journal of Translational Medicine, July 2014
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1 tweeter

Citations

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Title
Roles of CXCL5 on migration and invasion of liver cancer cells
Published in
Journal of Translational Medicine, July 2014
DOI 10.1186/1479-5876-12-193
Pubmed ID
Authors

Xiaojing Xu, Peixin Huang, Biwei Yang, Xiangdong Wang, Jinglin Xia

Abstract

Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related to liver cancer metastasis and investigating the potential mechanism by which cancer cells are recruited. We screened and validated inflammatory factors by microarray and RT-PCR. Small interfering RNA (siRNA) and recombinant protein were used to assess CXCL5 effects on the movement of liver cancer cells (LCCs). Our screening microarray demonstrated over-expression of CXCL5 in LCCs with high metastatic potentials. CXCL5 increased LCCs migration and invasion, probably through autocrine and paracrine mechanisms. CXCL5-CXCR2 and ERK1/2 pathways could play critical roles in the regulation of LCCs migration. Our data indicates that LCCs per se may act as the producer and receptor of CXCL5 responsible for liver cancer migration and invasion.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 32%
Student > Ph. D. Student 6 27%
Student > Bachelor 4 18%
Student > Master 1 5%
Librarian 1 5%
Other 0 0%
Unknown 3 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 27%
Immunology and Microbiology 4 18%
Agricultural and Biological Sciences 3 14%
Medicine and Dentistry 2 9%
Computer Science 1 5%
Other 1 5%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2014.
All research outputs
#18,987,311
of 21,343,037 outputs
Outputs from Journal of Translational Medicine
#3,087
of 3,687 outputs
Outputs of similar age
#170,898
of 202,741 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
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