Title |
Mathematical model insights into arsenic detoxification
|
---|---|
Published in |
Theoretical Biology and Medical Modelling, August 2011
|
DOI | 10.1186/1742-4682-8-31 |
Pubmed ID | |
Authors |
Sean D Lawley, Molly Cinderella, Megan N Hall, Mary V Gamble, H Frederik Nijhout, Michael C Reed |
Abstract |
Arsenic in drinking water, a major health hazard to millions of people in South and East Asia and in other parts of the world, is ingested primarily as trivalent inorganic arsenic (iAs), which then undergoes hepatic methylation to methylarsonic acid (MMAs) and a second methylation to dimethylarsinic acid (DMAs). Although MMAs and DMAs are also known to be toxic, DMAs is more easily excreted in the urine and therefore methylation has generally been considered a detoxification pathway. A collaborative modeling project between epidemiologists, biologists, and mathematicians has the purpose of explaining existing data on methylation in human studies in Bangladesh and also testing, by mathematical modeling, effects of nutritional supplements that could increase As methylation. |
X Demographics
Geographical breakdown
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United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
France | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
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Student > Master | 8 | 26% |
Researcher | 6 | 19% |
Student > Ph. D. Student | 4 | 13% |
Professor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 16% |
Unknown | 4 | 13% |
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Immunology and Microbiology | 2 | 6% |
Other | 5 | 16% |
Unknown | 9 | 29% |