Title |
Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models
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Published in |
BMC Bioinformatics, July 2014
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DOI | 10.1186/1471-2105-15-238 |
Pubmed ID | |
Authors |
Florian Martin, Alain Sewer, Marja Talikka, Yang Xiang, Julia Hoeng, Manuel C Peitsch |
Abstract |
High-throughput measurement technologies such as microarrays provide complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment vs. control design. Analysis of these information rich data can be guided based on a priori knowledge, such as networks or set of related proteins or genes. Among those, cause-and-effect network models are becoming increasingly popular and more than eighty such models, describing processes involved in cell proliferation, cell fate, cell stress, and inflammation have already been published. A meaningful systems toxicology approach to study the response of a cell system, or organism, exposed to bio-active substances requires a quantitative measure of dose-response at network level, to go beyond the differential expression of single genes. |
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Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
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Student > Ph. D. Student | 11 | 17% |
Student > Master | 11 | 17% |
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Student > Doctoral Student | 4 | 6% |
Other | 10 | 16% |
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