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Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

Overview of attention for article published in BMC Bioinformatics, July 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

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4 X users
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2 patents

Citations

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92 Dimensions

Readers on

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64 Mendeley
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Title
Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models
Published in
BMC Bioinformatics, July 2014
DOI 10.1186/1471-2105-15-238
Pubmed ID
Authors

Florian Martin, Alain Sewer, Marja Talikka, Yang Xiang, Julia Hoeng, Manuel C Peitsch

Abstract

High-throughput measurement technologies such as microarrays provide complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment vs. control design. Analysis of these information rich data can be guided based on a priori knowledge, such as networks or set of related proteins or genes. Among those, cause-and-effect network models are becoming increasingly popular and more than eighty such models, describing processes involved in cell proliferation, cell fate, cell stress, and inflammation have already been published. A meaningful systems toxicology approach to study the response of a cell system, or organism, exposed to bio-active substances requires a quantitative measure of dose-response at network level, to go beyond the differential expression of single genes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Brazil 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 19%
Student > Ph. D. Student 11 17%
Student > Master 11 17%
Student > Bachelor 5 8%
Student > Doctoral Student 4 6%
Other 10 16%
Unknown 11 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 22%
Biochemistry, Genetics and Molecular Biology 13 20%
Computer Science 11 17%
Medicine and Dentistry 6 9%
Mathematics 2 3%
Other 6 9%
Unknown 12 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2022.
All research outputs
#4,157,490
of 22,721,584 outputs
Outputs from BMC Bioinformatics
#1,610
of 7,261 outputs
Outputs of similar age
#41,169
of 226,363 outputs
Outputs of similar age from BMC Bioinformatics
#35
of 140 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,261 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.