Title |
Hepatogenic and neurogenic differentiation of bone marrow mesenchymal stem cells from abattoir-derived bovine fetuses
|
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Published in |
BMC Veterinary Research, July 2014
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DOI | 10.1186/1746-6148-10-154 |
Pubmed ID | |
Authors |
Fernando Dueñas, Víctor Becerra, Yennifer Cortes, Sonia Vidal, Leonardo Sáenz, Jaime Palomino, Mónica De los Reyes, Oscar A Peralta |
Abstract |
Mesenchymal stem cells (MSC) are multipotent progenitor cells characterized by their ability to both self-renew and differentiate into tissues of mesodermal origin. The plasticity or transdifferentiation potential of MSC is not limited to mesodermal derivatives, since under appropriate cell culture conditions and stimulation by bioactive factors, MSC have also been differentiated into endodermal (hepatocytes) and neuroectodermal (neurons) cells. The potential of MSC for hepatogenic and neurogenic differentiation has been well documented in different animal models; however, few reports are currently available on large animal models. In the present study we sought to characterize the hepatogenic and neurogenic differentiation and multipotent potential of bovine MSC (bMSC) isolated from bone marrow (BM) of abattoir-derived fetuses. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 24% |
Student > Master | 5 | 11% |
Researcher | 4 | 9% |
Student > Doctoral Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 5 | 11% |
Unknown | 14 | 30% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 20% |
Veterinary Science and Veterinary Medicine | 6 | 13% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 3 | 7% |
Unknown | 16 | 35% |